The Auburn Tigers and Florida Gators meet in an all-SEC clash to kick off the Final Four on Saturday. Then, the Duke Blue Devils square off with the Houston Cougars in the nightcap in San Antonio. Each battle between No. 1 seeds could produce games that are talked about for decades.

The 2025 NCAA Men’s Basketball tournament will be available across CBS, TBS, TNT, and truTV. (1) Florida vs. (1) Auburn, 6:09 p.m. on CBS

Final Four picks, predictions, odds for Duke Blue Devils vs Houston Cougars NCAA Tournament March Madness game Saturday, April 5, 2025. Who wins game?

The road to the Final Four of the men's NCAA Tournament has nearly reached its last stop.

According to DraftKings, Duke (+110) has the best odds to win the title entering the Final Four. Florida (+250), Houston (+400) and Auburn (+475) round out the rest of the Final Four teams. Gambling problem? Call (877-8-HOPENY) or text HOPENY (467369).

Often, by the time the NCAA Tournament reaches its fourth round - the Elite Eight - a few of the bracket's titans and blue-blood programs have already fallen in surprising upsets. While No. 1 seeds are given their spot in the bracket for a reason,

Florida and Duke  have already secured a spot in San Antonio for the 2025 Final Four. On Sunday, the Gators and Blue Devils will find out their semifinal opponents as champions emerge from the Midwest and South regions in Elite Eight action.

No. 1 seed Houston (34-4) defeated No. 2 seed Tennessee (30-8), 69-50, in the Elite Eight of the 2025 NCAA Tournament Sunday at Lucas Oil Stadium in Indianapolis, Indiana.

The odds of achieving a perfect bracket for the college basketball tournament are about 1 in 9.22 quintillion.