The findings suggest recombinant ADAMTS-13 may be a useful adjunct therapy to plasma exchange among patients who have thrombotic thrombocytopenic purpura (iTTP). Clearance of ADAMTS-13 mediated by ...

There is the Addams Family. And then there is the ADAMTS family. While one is mindless entertainment, the latter may prove to be a new genetic avenue for designing ovarian cancer treatment. Scientists ...

The ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family comprises a group of extracellular zinc-dependent endopeptidases that modulate the structure and function of the ...

Thrombotic thrombocytopenic purpura (TTP) is characterized by life-threatening destruction of intravascular erythrocytes and platelets, by mechanisms that remain poorly understood. In October 4 Nature ...

Finally, the molecular pathways involved were investigated. Adamts-7 overexpression led to increased expression of TNF and metalloproteinases associated with the development of OA. In addition, via ...