The effectiveness of any drug molecule depends on how well it interacts with the internal environment inside our body. Its pharmacokinetic (PK) properties determine how successfully it escapes ...

Linking molecular components through amide bonds is one of the most important reactions in research and the chemical industry. Scientists have now introduced a new type of reaction for making amide ...

In proteins, amino acids are held together by amide bonds. These bonds are long-lived and are robust against changes in temperature, acidity, or alkalinity. Certain medicines make use of reactions ...

Even though amide bonds are everywhere—they hold proteins together and are essential components in many drugs—forging this molecular motif in a reaction flask can be challenging. For example, making ...

Nuclear Magnetic Resonance (NMR) spectroscopy is a useful tool for exploring various domains across the natural sciences. NMR is well-suited to the analysis of molecular properties, such as the amide ...

A high-yield, one-pot, scalable reaction facilitates the production of biologically relevant amide compounds using less reactive nitrogen-containing heterocyclic compounds and carboxylic acid without ...

Amides are among the most ubiquitous functional groups in organic chemistry, forming the backbone of peptides and playing a vital role in pharmaceutical, synthetic and materials chemistry. Their ...

In proteins, amino acids are held together by amide bonds. These bonds are long-lived and are robust against changes in temperature, acidity or alkalinity. Certain medicines make use of reactions ...

Linking molecular components through amide bonds is one of the most important reactions in research and the chemical industry. In the journal Angewandte Chemie, scientists have now introduced a new ...

Figure 2. (Top) Adipic acid reacts with hexamethylenediamine to form an amide bond (red line), just like the reaction in Figure 1, but there's a big difference. The reaction product that I've called ...

Pfizer's Paxlovid looks very promising in fighting COVID. It also provides a good opportunity to learn about how enzyme inhibitors work. For masochists only. Although different chemists may have other ...