While we tend to quickly forget having been ill or having received a vaccine, the immune system remembers remarkably well. It has memory B cells—"trained" immune cells that circulate throughout the ...

Deep in the lungs, resident memory B cells stand guard against influenza reinfection—but whether they remain there may depend on how strongly they are signaled through their own receptors. New ...

Although CD4 T cells are critical orchestrators of protective immunity, vaccine strategies that optimize generation of these cells are not yet prioritized. In this manuscript, to mimic the typical ...

Scientists analyzing human and mouse pancreatic lymph nodes (PLNs) and spleens have identified a distinct subset of CD4 memory helper T cells associated with type 1 diabetes (T1D). Reported by ...

Lassa fever, a viral hemorrhagic fever caused by the arenavirus Lassa virus (LASV), affects thousands of individuals annually, highlighting the need for a vaccine. Yet, immunological correlates of ...

The experimental SchistoShield vaccine triggered strong B-cell and T-cell immune memory in early U.S. and African clinical trials.

A unique quality of the immune system is that it can generate a ‘memory’ response. This is generally referred to as ‘immune memory’ because of the body’s ability to remember previously encountered ...

The immune system can be further classified into the innate and adaptive immune systems. Although innate myeloid cells, such as macrophages, generate a ‘trained’ immune response following antigen ...

A new study led by researchers at Washington University School of Medicine in St. Louis has found that an investigational ...

A new Review reveals how aging can push the immune system into a paradoxical state, weaker against threats yet more prone to attacking the body’s own tissues.