Bilirubin, the primary breakdown product of hemoproteins, particularly hemoglobin, plays a key role in the diagnosis, prognosis, and monitoring of liver diseases. In acute liver diseases, such as ...

Data from two preclinical studies, one involving a mouse model of inflammatory bowel disease 1 and the other a mouse model of pancreatitis, 2 support the therapeutic effects of administrations of ...

While high bilirubin levels can indicate several health issues, low bilirubin levels usually aren’t anything to worry about. In some cases, it could be a side effect of a medication you take or having ...

Jaundice, characterized by yellowing skin and eyes, arises from bilirubin buildup due to red blood cell breakdown, liver dysfunction, or bile duct obstruction. Recognizing symptoms like dark urine, ...

Conjugation of bilirubin and delivery to the intestine doesn't necessarily lead to excretion of the substance. Neonatal intestines contain beta-glucuronidase, an enzyme capable of reducing bilirubin ...

In studies in mice, researchers report they have found that bilirubin, a bile pigment most commonly known for yellowing the skin of people with jaundice, may play an unexpected role in protecting ...

Phenobarbital causes a marked proliferation of the smooth-surfaced membranes of the endoplasmic reticulum in the liver cells. And, like many other compounds, it is an inducer of drug-metabolizing ...

Jaundice is when there is too much bilirubin in the blood. When this happens in a baby their eyes and skin develop a yellow coloring. Bilirubin is a yellow substance that is produced after the liver ...

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Bilirubin is a substance found in bile, a fluid produced in the liver that helps break down fats. High bilirubin levels (hyperbilirubinemia) can be caused by medical conditions like gallstones, ...

If a recent blood test shows elevated bilirubin levels, there’s a chance you could have a common and generally harmless genetic condition known as Gilbert Syndrome, which is pronounced “Jill-bear,” ...

Malaria is often associated with jaundice, where levels of the yellow pigment bilirubin are higher. In this study of mice, scientists show that bilirubin generated by the enzyme biliverdin reductase ...