Signal transduction is the fundamental process by which cells convert external cues into tailored intracellular responses. Through a cascade of molecular events—beginning at the cell membrane with the ...

Cell signaling is crucial for cells to communicate and function correctly. Disruptions in these pathways, caused by genetic mutations or environmental factors, can lead to uncontrolled cell growth, ...

Cancer stem cells (CSCs), a critical subpopulation within tumors, drive cancer initiation, progression, metastasis, relapse, ...

Which neoadjuvant treatment is best for locally advanced esophageal cancer? a systematic review and network meta-analysis. This is an ASCO Meeting Abstract from the 2025 ASCO Annual Meeting I. This ...

That’s gene editing. On paper, it is merely the rearrangement of letters. However, the road to editing genes in hopes of a therapeutic benefit is difficult to travel. Additionally, researchers want ...

Researchers at the Department of Pharmacology and Toxicology at the University Medical Center Göttingen (UMG) have discovered a key genetic regulatory mechanism that becomes disrupted in heart failure ...

A new research paper titled "Resistance of MMTV-NeuT/ATTAC mice to anti-PD-1 immune checkpoint therapy is associated with macrophage infiltration and Wnt pathway expression" has been published in ...

Pelvic pain in women with endometriosis is attributed to neuroinflammation. Researchers have investigated biochemical mediators of endometriosis-associated pelvic pain to provide a foundation to ...

J.M. Graff, A. Bansal, D.A. Melton, "Xenopus Mad Proteins Transduce Distinct Subsets of Signals for the TGFß Superfamily," Cell,85:479-87, 1996. (Cited in at least 120 publications to date) Comments ...

STRESSED OUT: Jöel Raingeaud, left, and Roger Davis found that the p38 MAP kinase is activated by inflammatory cytokines and environmental stress. J. Raingeaud, S ...