DNA does not float freely in the cell. Instead, it is wrapped around histone proteins to form structures called nucleosomes. These histones carry numerous chemical modifications that act as molecular ...

A mixture of DNA and proteins—known as "chromatin"—sits inside every cell nucleus as a jumbled puddle of genetic information. As cells prepare to divide during mitosis, the chromatin is condensed into ...

This provides us with a novel insight into the physical bases of mitotic chromosome condensation in living human cells," said Maeshima. "In this study, we discovered that mitotic chromosomes are ...

(A) Histone staining images and OI-DIC density imaging of human living cells in the interphase (the phase between cell divisions, left) and mitotic phase (right). The bottom two rows are OI-DIC ...