The idea that centrosome aberrations could drive tumour development was proposed more than 100 years ago and yet there is still uncertainty as to whether extra centrosomes are a cause or a consequence ...

Centrosomes are small structures in cells with many essential functions, including roles in cell signaling and in organizing a cell's cytoskeleton. Centrosome dysfunction contributes to diseases like ...

Various subcellular constituents, including transcripts, native and misfolded proteins, centrosomes and DNA, segregate asymmetrically during cell division into individual daughter cells. Evidence for ...

Unseen and ongoing, thousands of times every second: to keep a complex organism like humans alive, an immense number of new cells must be continuously produced. Up close, each of these cell divisions ...

Researchers provide insight into an old mystery in cell biology, and offer up new clues to understanding cancer. Scientists have unraveled the mystery of how cells count the number of centrosomes, the ...

When a cell is dividing, two identical structures, called centrosomes, move to opposite sides of the cell to help separate its chromosomes into the new cells. When a cell is dividing, two identical ...

The paper M.S. Levine et al., “Centrosome amplification is sufficient to promote spontaneous tumorigenesis in mammals,” Dev Cell, 40:313-22, 2017. Three’s a crowd More than a century ago, the German ...

The centrosome is the organelle responsible for the organization of the cytoskeleton during cell division, an essential function in organisms from yeast to humans. Until now, scientists assumed that ...

Centrosomes are small structures in cells with many essential functions, including roles in cell signaling and in organizing a cell’s cytoskeleton. Centrosome dysfunction contributes to diseases like ...

When cells extend, move, or divide, a tiny organelle called the centrosome provides a cytoskeletal anchor and regulatory hub. It was long held that centrosomes are similar in composition across cells.