SGLT2 inhibitors (gliflozins) were developed as oral antidiabetics. They enhance urinary glucose excretion by inhibiting SGLT-2 (sodium-dependent glucose co-transporter-2) in the renal tubuli. The ...

Niigata, Japan - The gold standard test for predicting the onset of diabetic kidney disease is albuminuria. However, detecting albuminuria alone has limited sensitivity and specificity in end-stage ...

Urea transporter (UT) proteins facilitate the passive transport of urea driven by a concentration gradient across the cell plasma membrane in some kidney and extrarenal cells The kidney expresses ...

ALTHOUGH many extensive investigations in animals 1–3 have demonstrated the existence of renal medullary hyperosmolality suggestive of a counter-current mechanism of urine concentration, direct ...