Cancer genomes are the result of diverse mutation processes that have often accumulated over decades. Scientists have analyzed the molecular evolution of tumors after exposure to mutagenic chemicals.

An artificial intelligence-predicted image of a region in the SPRTN enzyme (green structure) that can recognise and bind to ubiquitin chains (orange structure). Researchers at the University of Oxford ...

XPC protein acts as a sensor to detect various abnormalities in the DNA structure. The faithful repair of DNA is ensured by using the basal transcription factor TFIIH and XPA protein to verify the ...

A research team from the University of California (UC), Irvine, has revealed a previously unknown mechanism that triggers an inflammatory immune response in cells when their DNA is damaged. The ...

A team of international researchers at the University of Oxford (Oxford) and Nanyang Technological University, Singapore (NTU Singapore), has discovered a new process for repairing damaged DNA that is ...

PD is a neurodegenerative movement disorder with progressive loss of dopaminergic neurons that causes tremors, rigidity, bradykinesia, and postural instability. High-throughput markers are needed to ...

In a new study, scientists at the Max Planck Institute for Evolutionary Anthropology in Leipzig analyzed the impact of more ...

Due to the extremely rare overlap of mitochondrial DNA depletion syndrome type 3 and pediatric hepatocellular carcinoma, the case presents daunting therapeutic challenges.

BKPyV infection is often asymptomatic or mild during childhood, but may leave a lasting impact on cancer risk. In A Nutshell Nearly all adults (95%) carry BK polyomavirus from childhood infections ...

Not all DNA looks like the familiar double helix. Sometimes, parts of our genetic code fold into unusual shapes under certain conditions. One such structure known as a G-quadruplex (G4) looks like a ...