University of Queensland researchers have developed a drug that activates a hard-to-target immune receptor—a breakthrough ...

G-protein-coupled receptors (GPCRs) are one of the largest families of cell surface proteins in the human body that recognize hormones, neurotransmitters, and drugs. These receptors regulate a wide ...

Drug discovery is shifting from static snapshots to moving pictures. Instead of inferring how medicines work from end results, researchers are now watching individual molecules collide with cell ...

The landscape shifted dramatically with the emergence of fam-trastuzumab deruxtecan-nxki (T-DXd), an ADC that combines trastuzumab with a potent topoisomerase I inhibitor payload, deruxtecan, via a ...

G protein-coupled receptors (GPCRs) are the most abundantly expressed proteins in the human body, regulating diverse ...

Adenosine A 2A receptors (A 2A R) in the nucleus accumbens of the brain play an important role in regulating sleep and motivation, but until now, no drugs have been able to selectively modulate their ...

When many of us think about how drugs work in the body, we may first think about how a drug gets into the body, such as a pill versus an injection. In the Gellman Group at the UW–Madison Department of ...

Rendering a drug effective or ineffective in a flash at the appropriate location – this is the focus of research in photopharmacology. The goal is to develop drugs that can be switched on and off with ...