A team led by researchers from Tianjin University (P.R. China) has solved the structure of the Zika virus helicase, which is a key target for antiviral development. The research is published in ...

In eukaryotes, the Cdt1-bound replicative helicase core MCM2-7 is loaded onto DNA by the ORC–Cdc6 ATPase to form a prereplicative complex (pre-RC) with an MCM2-7 double hexamer encircling DNA. Using ...

Scientists have successfully described a crucial structure involved in DNA replication, placing another piece in the puzzle of how life propagates. Scientists at Van Andel Research Institute and ...

These are two images showing the structure of the helicase protein complex from above. (a) A surface-rendered three-dimensional electron density map as obtained by cryo-EM. (b) A computer-generated ...

In a recent study published in the PNAS Journal, researchers used a multidisciplinary approach to investigate a nonstructural protein essential in SARS-CoV-2 replication. They characterized the ...

RNA helicases are a group of enzymes that bind to and alter RNA in an ATP-dependent way. They play significant roles in RNA metabolism, gene expression regulation, and innate immunity. Different RNA ...

Like "The Little Engine That Could," helicases are hardworking enzymes that don't give up. Without them, your cells would stop dividing and many other important biological processes would come to a ...

Scientists have solved the structure of the Zika virus helicase, which is a key target for antiviral development. A team led by researchers from Tianjin University (P.R. China) has solved the ...

A team led by researchers from Tianjin University (P.R. China) has solved the structure of the Zika virus helicase, which is a key target for antiviral development. The research is published in ...