Scientists say their new insights into how a key brain protein works could help resolve a long-standing question in molecular neuroscience. Researchers supported by the National Institutes of Health a ...

In the mammalian CNS, the principle excitatory neurotransmitter is L-Glutamate, which acts through G-protein coupled (metabotropic) receptors and ligand gated ion channels (ionotropic receptors).

Neurotransmission at many central synapses can be regulated by various presynaptic ionotropic receptors. The regulatory mechanism depends on the properties of the receptor, as well as on the ...