Tandem mass spectrometry is a powerful tool in proteomics. By ionizing peptides and then fragmenting those ions into smaller product ions, researchers can determine the biomolecules’ amino acid ...

Recent advancements in mass spectrometry and computational tools enhance the feasibility of top-down proteomics. Top-down ...

The high-throughput nature of proteomics mass spectrometry is enabled by a productive combination of data acquisition protocols and the computational tools used to interpret the resulting spectra. One ...

Database searching is an essential element of large-scale proteomics. Because these methods are widely used, it is important to understand the rationale of the algorithms. Most algorithms are based on ...

AIF: All-ion fragmentation; DDA: Data-dependent acquisition; DIA: Data-independent analysis; HCD: Higher energy collisional dissociation; IDENTITY: Ion Accounting ...

During the process of research and development of antibody drug molecules, an essential step is determining the sequence of the antibody. Mass spectrometry technologies have advanced so far as to make ...

For glycopeptide characterization, mass spectrometry has arisen as the go-to methodology. As well as the instrumental arrangement, a suitable software solution is essential to enable glycopeptide ...

To find out the molecular weight of a compound is the basic task for mass spectrometry. If this is done precisely, it is possible to determine the elemental composition. If there are isomers with ...

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