Modern single-molecule tools, when applied to enzymes, challenge fundamental concepts of catalysis by uncovering mechanistic pathways, intermediates and heterogeneities hidden in the ensemble average.

An increase in nutrient dose leads to proportional increases in crop biomass and agricultural yield. However, the molecular underpinnings of this nutrient dose–response are largely unknown. To ...

Cells send signals through enzyme cascades, where one enzyme passes the signal to the next. In such cascades, it is crucial that the enzyme recognizes the right substrates to ensure that, for example, ...

Enzymes are biological catalysts that facilitate biochemical transformations. An international team of bioinformatics researchers has developed a new process for predicting Michaelis constants, which ...

This is a preview. Log in through your library . Abstract Systematic errors caused by some methods of estimating the parameters of a rectangular hyperbola are discussed using a second-order Taylor ...

Enzyme kinetics involves the measurement of the rate at which chemical reactions that are catalyzed by enzymes occur. Knowledge about the kinetics of an enzyme can reveal useful information about its ...

SAN FRANCISCO--(BUSINESS WIRE)--Menten AI, Inc., a biotechnology company with a generative AI platform for design and optimization of peptide macrocycles, today announced the completion of a ...

Influence of single agent gemcitabine (GEM) schedule on the pattern of response and toxicity in patients with advanced pancreas, lung and breast carcinoma: A systematic review No significant financial ...

A team of mathematicians and pharmaceutical scientists collaborated to identify the major cause of the low accuracy of the equation in the FDA guidance used to predict drug-drug interaction through an ...