Researchers at The Institute of Cancer Research, London identified the CIP2A–TOPBP1 complex as a master regulator of DNA repair during mitosis, coordinating backup pathways that protect chromosomes ...

Cells can measure how long they spend in mitosis. If mitosis is prolonged due to problems during chromosome separation, the Mitotic Stopwatch Complex is formed, which may lead to cell arrest or cell ...

(A) Histone staining images and OI-DIC density imaging of human living cells in the interphase (the phase between cell divisions, left) and mitotic phase (right). The bottom two rows are OI-DIC ...

Replication origins in eukaryotic cells initiate a single round of DNA synthesis in each cell cycle. This requires the regulated binding of several conserved initiation proteins, including CDC6/Cdc18p ...

Researchers have found a molecular mechanism that prevents multiplication of potentially dangerous cells by measuring the duration of mitosis. They have shown that this mechanism -- the Mitotic ...