Adenylosuccinate lyase (ADSL) deficiency is an inherited metabolic disorder that impairs purine metabolism. ADSL is a key enzyme in both the de novo synthesis and the purine nucleotide cycle, ...

Parkinson's disease (PD), the second most common neurodegenerative disorder globally, has long baffled scientists with its progressive nature and debilitating effects on motor function. A recent study ...

Gut microbiota capable of metabolizing uric acid and purines may play a key role in reducing gout diagnoses, and although the findings from new retrospective and prospective studies suggest key roles ...

Researchers at the University of Michigan Health Rogel Cancer Center are one step closer to understanding how pediatric DIPG tumors work. Diffuse intrinsic pontine glioma, or DIPG, is the most ...

High uric acid in the body can quietly create pain in joints, trigger gout, and affect daily movement. It forms when the body ...

A new clinical trial from a team at the University of Michigan Rogel Cancer Center uses innovative basic science research methods to offer hope and a new treatment to glioblastoma patients. A ...

Why do uric acid levels rise after festivals and holidays, and how can you control them naturally with diet and hydration ...

High uric acid levels can silently damage joints and kidneys if ignored. Knowing which foods worsen the condition can help ...