A review paper by scientists at the University of Oxford highlights recent advancements in SMTE, including innovations in ...

Muscles are formed by the merging of many small myoblasts into larger myofibers. This fusion of mononucleated myoblasts with a single nucleus into multinucleated myofibers with multiple nuclei is an ...

Because RyR1 is also expressed in neurons, immune cells, and vascular smooth muscle, the E3896A model offers a unique tool to examine CICR's broader physiological roles. By combining gene engineering, ...

The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...

Penn Medicine researchers unveiled in a recently published paper that a type of stem cell originating in skeletal muscle cells can turn into bone. Published in the Proceedings of the National Academy ...

For more than 30 years, scientists have studied how the myogenic determination gene number 1 (MYOD) protein binds DNA to modify the gene expression of muscle stem cells. Similar to the instant kung fu ...

In a finding that opens the door to the development of targeted therapies for various muscle disorders, newly published research identifies key mechanisms of skeletal muscle regeneration and growth of ...

Researchers corrected lamin A gene mutations, preventing skeletal and cardiac abnormalities and extending mice lifespans.