San Francisco 49ers quarterback Brock Purdy was ruled out of the team's matchup with the Tampa Bay Buccaneers on Sunday with a toe injury, according to NFL Network's Ian Rapoport.

Jackson finished with five carries for 35 yards and scored a 29-yard rushing touchdown with 4:21 remaining in regulation to extend USC's lead to 18. The running back who got the bulk of the work with Sanders and Jordan out was King Miller, who ran for 156 yards and a touchdown.

San Francisco 49ers quarterback Brock Purdy is still sidelined by a toe injury and missed practice on Wednesday.

San Francisco 49ers head coach Kyle Shanahan said Wednesday that quarterback Brock Purdy is "progressing" and that he hasn't thought about placing the fourth-year quarterback on injured reserve.

Joe Burrow will reportedly undergo surgery for his Grade 3 turf toe injury. But what is turf toe? Here's what to know.

The Dallas Cowboys placed Malik Hooker on injured reserve Saturday, sidelining one of their starting safeties at least four games after he injured a left toe last weekend in a game against Green Bay.

Cincinnati Bengals quarterback Joe Burrow is expected to be out for months after he sustained a toe injury on Sunday during a game against the Jacksonville Jaguars.

While it sounded like a short turnaround was the main reason for Brock Purdy ‘s absence from tonight’s Week 5 contest, the 49ers QB may actually be sidelined for more than just this week. According to NFL Network’s Ian Rapoport, Purdy suffered a setback with his turf toe injury and is now considered week-to-week.

Quarterback Brock Purdy returns for the San Francisco 49ers this week after missing two games with a toe injury.

San Francisco 49ers quarterback Mac Jones will "likely" start under center during a matchup with the Tampa Bay Buccaneers on Sunday, according to CBS Sports' Matt Zenitz.

The San Francisco 49ers get worrying news about quarterbacks Mac Jones and Brock Purdy ahead of their Week 6 game.