Transcription is the first step of gene expression, where a DNA sequence is copied into messenger RNA. In eukaryotes, transcription initiation starts with the assembly of the transcription ...

The regulation of mRNA transcription plays a key role in relaying signals from the environment and during development into the gene expression program of a cell. During transcription initiation, a ...

Transcription initiation and elongation of HIV-1 are critical processes regulating viral latency and activation. Despite these two processes playing essential roles in HIV-1 gene expression, how they ...

Rosalind Franklin, James Watson and Francis Crick discovered the structure of DNA -- that molecular blueprint for life -- over 70 years ago. Today, scientists are still uncovering new ways to read it.

The human genome contains approximately 1,600 types of transcription factors responsible for regulating gene activity across ...

Northwestern Medicine scientists have discovered how molecular "traffic controllers" in cells influence aging and cellular ...

Sequence-specific, DNA-binding TFs are the major regulators of cell identity and cell physiology. As examples, expression of select TFs can revert differentiated cells back to a pluripotent state and ...

A newly discovered promoter element "start" points to a shared regulatory syntax for controlling transcription initiation in ...

Some things just go together like “rock and roll” and “fish and chips” or, in molecular biology, “transcription factors” and the “nearby genes they regulate.” The standard, simplified story goes like ...

Transcription factors are the most powerful genes in our body. They are master regulators and have been implicated in our biggest diseases, even aging itself. Yet, many in the pharmaceutical industry ...