Familiar matchups abound on the NFL Week 10 schedule as there are half a dozen divisional games you can make Week 10 NFL picks on. The highlight of that slate is Rams vs. 49ers, which has L.A. as the 5.5-point road favorite, per the latest NFL odds.

The 2025 NFL schedule has moved into double digits as we reach Week 10 of the year. Teams are starting to position themselves for the playoffs, trying to make up for struggles in the first half of the year, or starting to look toward 2026 already.

KC Joyner's confidence picks have been on a roll lately. This week, his top picks are the Seahawks, Rams and Broncos.

It wasn’t a pretty first half, but the San Francisco 49ers bounced back to blow out the Cleveland Browns in Week 13.

Patrick Mahomes and the Kansas City Chiefs take on Dak Prescott and the Dallas Cowboys in a Thanksgiving Day NFL matchup on Thursday at AT&T Stadium.

Expert recap and game analysis of the Carolina Panthers vs. Los Angeles Rams NFL game from November 30, 2025 on ESPN.

On Sunday, the Atlanta Falcons (4-7) will face off against the New York Jets (2-9) in a battle between two of the most mediocre teams in the NFL. The Falcons have been bad, but the Jets have been even worse.

Follow live team news, score updates & text coverage of the NFL Thanksgiving triple-header, with Cowboys beating Chiefs after Packers win at Lions