Gut

Beyond the usual suspects: haemorrhagic shock secondary to massive obscure gastrointestinal bleeding

A 49-year-old woman with alcohol-related cirrhosis (Child-Pugh B8, MELD 11) and 11 months of abstinence presented with per ...
Gut

KIF13B emerges as a key player in alcohol-associated liver steatosis

Alcohol-associated liver disease (ALD) is a major global health problem and a leading cause of liver-related morbidity and ...
Gut

Beyond Spigelman: time-adaptive duodenal cancer risk in familial adenomatous polyposis – results from a retrospective two-centre study (DRACO)

Background Duodenal cancer is a leading cause of cancer-related mortality in familial adenomatous polyposis (FAP), yet the ...
gut.bmj

Thrombopoietin concentrations are low in patients with cirrhosis and thrombocytopenia and are restored after orthotopic liver transplantation

BACKGROUND Thrombocytopenia in cirrhotic patients may be due to deficient production of thrombopoietin. AIMS To determine the relation between thrombopoietin and thrombocytopenia in cirrhotic patients ...
gut.bmj

Effect of azithromycin on acid reflux, hiatus hernia and proximal acid pocket in the postprandial period

1 Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands 2 Department of Nuclear Medicine, Academic Medical Center, Amsterdam, The Netherlands 3 Department ...
gut.bmj

Comparison of efficacy of pharmacological treatments for chronic idiopathic constipation: a systematic review and network meta-analysis

Objective To compare efficacy of pharmacotherapies for chronic idiopathic constipation (CIC) based on comparisons to placebo using Bayesian network meta-analysis. Data sources We conducted searches ...
gut.bmj

PEG 3350 (Transipeg) versus lactulose in the treatment of childhood functional constipation: a double blind, randomised, controlled, multicentre trial

3 Department of Paediatrics, Meander Medisch Centrum, Amersfoort, the Netherlands 4 MediServ BV/Clinical Research facilities BV, Schaijk, the Netherlands Correspondence to: Dr W P Voskuijl Department ...
gut.bmj

SPECT imaging of the stomach: comparison with barostat, and effects of sex, age, body mass index, and fundoplication

Background: Impaired gastric accommodation may lead to dyspeptic symptoms. A non-invasive method using single photon emission computed tomography (SPECT) has been developed to measure gastric volumes.
gut.bmj

Randomised controlled trial of azathioprine and 5-aminosalicylic acid for treatment of steroid dependent ulcerative colitis

Background and aim: There are limited evidence based data concerning the use of azathioprine in ulcerative colitis. We aimed to compare the efficacy of azathioprine and oral 5-aminosalicylic acid in ...
gut.bmj

Case–control studies of risk factors for primary biliary cirrhosis in two United Kingdom populations

Objective The aetiology of primary biliary cirrhosis (PBC) is largely unknown. Previous studies have indicated that both environmental and genetic risk factors may be important. Design We undertook a ...
gut.bmj

A simple AGED score for risk classification of primary liver cancer: development and validation with long-term prospective HBsAg-positive cohorts in Qidong, China

Correspondence to Professor Jianguo Chen, Department of Etiology, Qidong Liver Cancer Institute, Qidong People’s Hospital, Qidong 226200, China; chenjg{at}ntu.edu.cn and Professor Hong Tu, State Key ...
gut.bmj

International expert panel review for the use of resmetirom and semaglutide in the management of MASH-related fibrosis: clinical practice update

The recent conditional US Food and Drug Administration (FDA) approval of two therapies, resmetirom (Rezdiffra) and semaglutide (Wegovy), marks the first time clinicians have pharmacological therapy ...