High point totals mean opportunity, and several key matchups stand out as potential fantasy goldmines in Week 10. Week 10 of the NFL season is already upon us, and the challenge of setting lineups and finding an edge in fantasy football only becomes greater than the week before.

The 49ers have suffered several injuries, yet they are still finding convincing ways to win, and they always play Sean McVay and his Rams tough. Keep an eye out for the line to move as the 49ers may get healthier by Sunday, they may even get back starting quarterback Brock Purdy.

After one week back at home in Los Angeles, the Rams will be on the road again in Week 10 for a pivotal matchup with the San Francisco 49ers. It’s a rematch of their Week 5 game that went into overtime,

Week 8's loss to the Houston Texans was a tough setback for the San Francisco 49ers, who had entered the game atop the NFC West standings. The defeat dropped San Francisco to the seventh seed in the conference playoff picture.

Sean McVay shared another update on Puka Nacua Monday, saying he's "optimistic" about the Rams WR heading into Week 10.

The 49ers haven't had Brock Purdy since Week 4, and amid reports of his potential return Sunday against the Rams, coach Kyle Shanahan said Purdy may be dealing with the injury the rest of the year.

Rams HC Sean McVay has an update on star WR Puka Nacua, who exited Sunday's blowout win vs. Saints with a chest/ribs injury

Matthew Stafford thrived once again for the Rams while the 49ers were ruthlessly efficient in Week 9 wins.

The Los Angeles Rams got a landmark performance out of Pro Bowl running back in Week 9 against the New Orleans Saints.

Jordan Schultz says the 49ers are looking for a defensive end or a linebacker ahead of the upcoming trade deadline, with an emphasis on edge rusher.  NFL