Seeing his first game action of the preseason, second-year quarterback Caleb Williams led the Chicago Bears 92 yards for a touchdown on the opening possession at Soldier Field.

One of the biggest preseason delights for Chicago has been defensive end Austin Booker, who has four sacks already. After picking up his fourth sack of the preseason in this game against Buffalo, Booker met with the medical staff and then was later ruled out with a knee injury.

The Buffalo Bills took on the Chicago Bears and lost in a 38-0 fashion in the second weekend of the 2025 NFL preseason. Sometimes the stats can tell the story of who performed well and who did not, but Pro Football Focus is there to provide a little bit more context.