Few would have expected the lowly New York Giants to be a matchup of particular importance for the San Francisco 49ers, but the stakes have heightened entering Sunday, columnist Ann Killion writes.

If the San Francisco 49ers want to stay in the fight to win the NFC West division, they will need a road win on November 2 against the New York Giants. Moreover, the Niners know that to accomplish this,

Christian McCaffrey and the San Francisco 49ers hope to get back on track running the ball against the New York Giants and their 30th-ranked rush defense

That moment was 11 years ago. Posey played six more seasons, retired and became the Giants’ president of baseball operations. Vitello became University of Tennessee’s head coach, turned the Vols into a collegiate powerhouse, and now is making the unprecedented leap from collegiate head coach to major-league manager.

The San Francisco Giants can end their rotation of second basemen by pursuing this All-Star in free agency this offseason. The San Francisco Giants have their future locked in at three of their four infield positions.

Get a prediction, pick and odds for the NFL Week 9 matchup between the San Francisco 49ers and the New York Giants.

Cornerback Art Green (hamstring) and defensive lineman Chauncey Golston (neck) also did not practice. Tight end Daniel Bellinger (neck), right tackle Jermaine Eleumunor (pectoral) and cornerback Cor’Dale Flott (concussion) were also not participating.

Yes, the 49ers are flying to the East Coast for a 1P kickoff. Yes, there is limited tape on rookie signal-caller Jaxson Dart. Giants' fans have to hope those factors play into this game because the rosters and coaching staffs point towards a 49ers' win.