The accurate replication of genetic material DNA is one of the most fundamental biological processes essential for the survival, growth, and reproduction of all living organisms. Eukaryotes, including ...

At each cell division in humans, DNA replication starts from 50,000 DNA replication origins, which are at specific locations along the chromosomes and from which DNA synthesis proceeds bidirectionally ...

Our lab studies the mechanism of eukaryotic chromosome replication. Chromosomes are the carriers of the genetic and epigenetic information and faithful chromosome replication is of fundamental ...

A.G. performed all the experiments except for the Mrc1, Tof1 and Csm3 ChIP experiments in Fig. 6c, which were carried out by M.K, and the purification in Supplementary Information, Fig. S1, which were ...