PNAS

Autophagy activator AA-20 improves proteostasis and extends Caenorhabditis elegans lifespan

Contributed by Jeffery W. Kelly; received November 13, 2024; accepted May 21, 2025; reviewed by Ana Maria Cuervo and Kerry Kornfeld ...

Unlocking the molecular blueprint for a powerful plant-based drug

Researchers at UBC Okanagan have uncovered how plants produce mitraphylline, a rare natural compound that may help fight ...
eLife

High-content high-resolution microscopy and deep learning-assisted analysis reveals host and bacterial heterogeneity during Shigella infection

High-content high-resolution microscopy coupled with deep learning-based analysis reveals novel phenotypes at the single-cell level during Shigella infection.
Technology Networks

Mechanism Underlying Sex-Specific Activity of Brown Adipose Tissue Identified

New research has uncovered a mechanism that explains why brown adipose tissue is more metabolically active in females.
C&EN

Visible-Light-Driven [2+2] Cycloaddition of Coumarins with Diverse Olefins Using a 4CzIPN Photosensitizer: Application to the Total Synthesis of (±)-Lindleyanin

Cyclobutane scaffolds represent essential structural motifs in bioactive natural products; however, their synthesis often requires high-energy ultraviolet radiation or costly transition metal ...
Frontiers

An analysis of the intestinal microbiome combined with metabolomics to explore the mechanism of how Pangxiejiao tea improves metabolic disorders in HFFD-treated rats

1 Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine (Institute of Chinese Medicine), Guangdong Pharmaceutical University, Guangzhou, China 2 Guangdong Provincial ...
C&EN

Regio- and Chemoselective Synthesis of Spiro Cyclobutane-Isobenzofuranimines via Cascade Oxycyclization and [2 + 2] Cycloaddition of o-Alkynolbenzamides

The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.joc.4c03092. Most electronic Supporting Information files are available ...
Frontiers

Roles of non-specific lipid transfer proteins in plant defense: structural and functional perspectives

Non-specific lipid transfer proteins (nsLTPs) are vital and versatile components of plant cellular systems. They are characterized by a conserved eight-cysteine motif and are increasingly recognized ...