Many believe that mast cell activation syndrome (MCAS) can never be treated or meaningfully improved. In my experience, non-IgE mediated MCAS patients can actually improve significantly. By identifying as many triggers and mediators as possible, by practicing as many principles of the Health Cycle as possible, by repairing the Cell Danger Response and reducing systemic inflammation through the application of the correct signaling molecules, many people are able to stop using mast cell blockers,