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If you needed another reason to try New Restylane® Refyne and New Restylane® Defyne, here are 10! The most commonly observed side effects are swelling, redness, pain, bruising, headache, tenderness, lump formation, and itching at the injection site. To learn more about serious but rare side effects and full Important Safety Information, visit www.RestylaneUSA.com. | Restylane USA